Last checked November 2026 against 14 sources · Editorial policy

OLLY Mellow Menopause review: does it work, and is the dose safe?

OLLY Mellow Menopause is a hormone-free capsule with EstroG-100, a blend of three Asian root extracts, plus GABA. It costs $29.99 for 30 capsules. Its main trial was small, lasted 5 weeks and was run by OLLY staff. The tested dose of EstroG-100, 514 mg, is about three times what Europe's food safety agency accepts as safe for daily use.

OLLY Mellow Menopause checked: EstroG-100 plus GABA for $29.99, a 5-week trial run by OLLY staff, and a dose about 3 times the EU safety limit. Better-studied options.

Find your stage · 2 min 14 sources

OLLY Mellow Menopause: expectation vs reality

What people often expect

“OLLY Mellow Menopause is a gentle gummy-brand vitamin that's clinically proven for 11 symptoms”

What the evidence shows

It's a capsule, not a gummy, and the 11 symptoms come from a 2012 trial of 64 women that tested EstroG-100 alone. OLLY's own trial of the full product had 80 women, lasted 5 weeks and was written by OLLY employees. The European Food Safety Authority limits EstroG-100 to 175 mg a day because of liver and blood findings in animal studies.

OLLY Mellow Menopause review: ingredients, trials and safety

What's in OLLY Mellow Menopause

OLLY lists two actives: EstroG-100, a blend of Angelica gigas, Cynanchum wilfordii and Phlomis umbrosa root extracts, and GABA, an amino acid sold for relaxation. The page doesn't print the dose of either, but says the capsule holds a clinically studied dose. In OLLY's published trial the product contained 514 mg of EstroG-100 and 50 mg of GABA. You take one capsule a day with water.

OLLY's own Mellow Menopause trial

The 2025 trial in the journal Menopause randomized 80 women to the EstroG-100 and GABA product or placebo. In week 1 they took it only when hot flashes started, then daily in weeks 2 to 5. Hot flashes fell in number and intensity versus placebo, and sleep, tension and mood scores improved. Three of the five authors work for OLLY, the maker of Mellow Menopause, and the trial lasted only 5 weeks.

The older EstroG-100 trials behind the 11 symptoms

OLLY's claim of support for 11 symptoms echoes a 2012 trial in which EstroG-100 alone was tested against placebo for 12 weeks in 64 women. The Kupperman index, a score of 11 symptoms, dropped from 29.5 to 11.3 on EstroG-100 and from 29.2 to 23.7 on placebo. A 2023 study in 60 Indian women had no placebo group, and two of its three authors came from the distributor's medical affairs team.

The OLLY Mellow Menopause dose vs Europe's safety limit

EstroG-100 needed approval as a novel food in the EU. The European Food Safety Authority judged it safe in supplements at up to 175 mg a day for postmenopausal women, lower than the 514 mg a day the applicant wanted. The panel based that limit on liver and blood effects seen in animal toxicity studies and on missing long-term data. OLLY's trial dose was the full 514 mg.

GABA in Mellow Menopause

GABA is a calming messenger in the brain, and OLLY adds it for relaxation and stress. The OLLY trial tested GABA and EstroG-100 together, so it can't show what GABA adds on its own. The 2023 Menopause Society position statement on nonhormone therapy doesn't recommend herbal supplements for hot flashes, because the evidence for them is weak or mixed. Hot flash relief, if any, most likely comes from EstroG-100.

OLLY Mellow Menopause price and subscription

On OLLY's site a 30-capsule bottle, a one-month supply, costs $29.99, and a subscription takes 15% off. That's about a dollar a day. OLLY says to take it daily and that it works on hot flashes, mood swings and stress within 28 days. Give it the full 28 days, then decide; if nothing changes by then, the longer trials offer little reason to keep paying.

Is OLLY Mellow Menopause a gummy?

No. OLLY is best known for gummy vitamins, and many people search for OLLY menopause gummies, but Mellow Menopause comes as 30 capsules that you swallow whole. If you want a chewable, our ranking of menopause gummies compares Estroven, AZO, O Positiv and MaryRuth's by dose and evidence. The capsule form doesn't change how the extract works; it's the same once-daily dose.

Learn more →

OLLY Mellow Menopause by the numbers

514 mg

of EstroG-100 in the product OLLY tested, with 50 mg of GABA

175 mg

a day is the EstroG-100 limit the European Food Safety Authority judged safe

women took part in OLLY's 5-week trial

$29.99

for 30 capsules, a one-month supply, on OLLY's site

Trial results come from short studies, two of them run or written by the companies selling EstroG-100.

We may earn a commission if you buy through links on this page. It doesn't change what we recommend. How this works →

OLLY Mellow Menopause vs other hot flash options

OLLY Mellow Menopause
Good for
One capsule a day; a placebo-controlled trial of the exact product; $29.99 a month.
Watch
Trial was 5 weeks and run by OLLY staff; dose is above the EU safety limit for EstroG-100.
Estroven Complete (rhapontic rhubarb, ERr 731)
Learn more →
Good for
The extract has several placebo-controlled trials, including a 12-week trial in 109 perimenopausal women.
Watch
Results come from trials linked to the extract's maker; one caplet a day.
Check price on Amazon →
Bonafide Relizen (pollen extract)
Learn more →
Good for
Hormone-free and studied after breast cancer; no significant side effects in a 2024 meta-analysis.
Watch
The benefit faded when only controlled studies were pooled; takes up to 3 months.
Check price on Amazon →
Bonafide Thermella (curcumin)
Learn more →
Good for
Two tablets a day; Bonafide reports fewer hot flashes by day 14 in its own trials.
Watch
Bonafide's trials are unpublished data; bioavailable curcumin has rare liver reports.
Check price on Amazon →
Prescription hot flash treatment
Learn more →
Good for
Hormone therapy and approved non-hormonal drugs have large trials behind them.
Watch
Needs a prescription and a check of your health history.

Before you buy OLLY Mellow Menopause

Note that the label doesn't print the EstroG-100 dose; OLLY's trial used 514 mg, above the 175 mg EU limit.
If you've liver disease or a blood disorder, ask your doctor first; the EU limit rests on liver and blood findings in animals.
Count your hot flashes for a week before you start and again at day 28, the point OLLY names for results.
Don't stack it with other menopause blends; you can't tell which product is working, and doses add up.
Supplements don't need FDA approval before sale, so the maker alone vouches for what's in the capsule.

When to stop OLLY Mellow Menopause and see a doctor

Urgent: Yellow skin or eyes, dark urine or pain under the right ribs on OLLY Mellow Menopause
Stop the capsules and get liver blood tests promptly.
Urgent: Unusual bruising or bleeding
Stop it and see a doctor; the EU safety review flagged blood effects in animal studies.
Bleeding after menopause
Any bleeding a year or more after your last period needs a doctor's check, whatever supplement you take.
More →
Hot flashes that still disrupt sleep or work after a month
Talk to a doctor about treatments with stronger evidence.
More →

OLLY Mellow Menopause reviews: questions women ask

Does OLLY Mellow Menopause work?

In OLLY's 5-week trial of 80 women, hot flashes fell in number and intensity more than on placebo, and sleep and mood scores improved. That's a real controlled result, but the trial was small, short and written mostly by OLLY employees. An older 12-week trial of EstroG-100 alone also beat placebo. Independent replication is still missing.

What are the side effects of OLLY Mellow Menopause?

The published trials reported no serious side effects, and the 2012 EstroG-100 trial found no weight gain. The open question is longer use: Europe's food safety panel capped EstroG-100 at 175 mg a day because of liver and blood findings in animals and a lack of long-term human data. Stop it if you notice jaundice, dark urine or unusual bruising.

What are the ingredients in OLLY Mellow Menopause?

EstroG-100, a blend of Angelica gigas, Cynanchum wilfordii and Phlomis umbrosa root extracts, plus GABA. OLLY's product page doesn't print the amounts. In the company's published trial the product held 514 mg of EstroG-100 and 50 mg of GABA. It contains no hormones.

When should I take OLLY Mellow Menopause?

OLLY says to take one capsule a day with water, swallowed whole, and to take it daily for best results. In the trial, women first took it as needed when a hot flash began, then daily. Any time of day works; pick one you'll remember.

How long does OLLY Mellow Menopause take to work?

OLLY says it works on hot flashes, mood swings and stress within 28 days. In its trial, hot flash changes showed up in the first days, but the whole study lasted only 5 weeks, so nobody knows how well it holds up over months.

Is OLLY Mellow Menopause safe for long-term use?

There's no long-term data. The longest controlled trial of EstroG-100 lasted 12 weeks. The European Food Safety Authority set a ceiling of 175 mg a day partly because chronic toxicity data were missing. OLLY's trial dose was 514 mg. If you plan to take it for months, tell your doctor and consider a liver test.

OLLY Mellow Menopause vs Estroven: which is better?

Both are hormone-free. Estroven Complete uses rhapontic rhubarb extract ERr 731, which has more placebo-controlled trials, including 12 weeks in 109 perimenopausal women. OLLY uses EstroG-100 plus GABA, with one 5-week trial of the product. On evidence, Estroven is ahead; on price they're close.

Is OLLY Mellow Menopause FDA approved?

No. It's a dietary supplement, and supplements don't need FDA approval before they're sold. The maker is responsible for safety and labeling, and the FDA steps in only after problems appear. Look for a third-party seal such as USP if you want outside testing of what is in the bottle.

Sources

See our editorial policy.