Last checked November 2026 against 21 sources · Editorial policy
Best menopause gummies, ranked by dose and evidence
The best menopause gummies, ranked by dose and evidence: 1. Estroven Complete Gummies, whose rhubarb extract has placebo-controlled trials; 2. AZO Menopause Relief Daytime, with 30 mg of genistein; 3. O Positiv MENO, a black cohosh, chasteberry and ashwagandha blend; 4. MaryRuth's Organic, with only 14.1 mg of herbs per serving, including St. John's wort. Prices run $0.68 to $1.40 a day.
Menopause gummies ranked: Estroven, AZO, O Positiv MENO and MaryRuth's compared by active dose, trials, sugar, price per day and safety, plus OLLY Mellow Menopause.
Menopause gummies side by side
| 1. Estroven Complete Gummies | 2. AZO Daytime Gummies | 3. O Positiv MENO | 4. MaryRuth's Organic | |
|---|---|---|---|---|
| Active ingredient | Rhapontic rhubarb root extract (ERr 731), the same as Estroven caplets. | Genistein, a soy isoflavone, 30 mg. | Ashwagandha 150 mg (KSM-66), black cohosh extract 40 mg, chasteberry extract 40 mg. | Blend of maca, kudzu, black cohosh and St. John's wort, 14.1 mg in total. |
| Gummies a day | 1 | 1 | 2 | 2, up to 2 times a day |
| Price on the brand's site | $26.48 for 30, or $0.88 a gummy. | $20.49 for 30, or $0.68 a gummy. | $41.99 a bottle, $34.99 on subscription; 30 servings. | $29.95 for 60, $26.96 on subscription. |
| Best evidence for the active | Meta-analysis of 4 trials, 390 women: symptom scores fell vs control. | Genistein cut flushes vs placebo at 54 mg a day; Cochrane saw benefit above 30 mg. | Cochrane: black cohosh no better than placebo for hot flash frequency. | No trial of the blend; doses far below those studied. |
| Main caution | Trials linked to the extract's maker. | A phytoestrogen; ask first after breast cancer. | Ashwagandha and black cohosh have rare liver injury reports. | St. John's wort interacts with birth control pills and many medicines. |
| 1. Estroven Complete Gummies | 2. AZO Daytime Gummies | 3. O Positiv MENO | 4. MaryRuth's Organic | |
|---|---|---|---|---|
| Active ingredient | Rhapontic rhubarb root extract (ERr 731), the same as Estroven caplets. | Genistein, a soy isoflavone, 30 mg. | Ashwagandha 150 mg (KSM-66), black cohosh extract 40 mg, chasteberry extract 40 mg. | Blend of maca, kudzu, black cohosh and St. John's wort, 14.1 mg in total. |
| Gummies a day | 1 | 1 | 2 | 2, up to 2 times a day |
| Price on the brand's site | $26.48 for 30, or $0.88 a gummy. | $20.49 for 30, or $0.68 a gummy. | $41.99 a bottle, $34.99 on subscription; 30 servings. | $29.95 for 60, $26.96 on subscription. |
| Best evidence for the active | Meta-analysis of 4 trials, 390 women: symptom scores fell vs control. | Genistein cut flushes vs placebo at 54 mg a day; Cochrane saw benefit above 30 mg. | Cochrane: black cohosh no better than placebo for hot flash frequency. | No trial of the blend; doses far below those studied. |
| Main caution | Trials linked to the extract's maker. | A phytoestrogen; ask first after breast cancer. | Ashwagandha and black cohosh have rare liver injury reports. | St. John's wort interacts with birth control pills and many medicines. |
Menopause gummies: expectation vs reality
What people often expect
“Menopause gummies are a tasty, natural way to stop hot flashes, and they all work about the same”
What the evidence shows
The four bestsellers share a format, not a formula. One uses an extract with several placebo-controlled trials, one a soy isoflavone at the threshold where trials start to show benefit, one an herb Cochrane found no better than placebo, and one a 14.1 mg blend that includes St. John's wort, which interacts with birth control pills.
How we ranked menopause gummies
How we ranked menopause gummies
We read each label on the brand's site in November 2026 and ranked the gummies on three things: whether the active ingredient has placebo-controlled trials for menopause symptoms, whether the dose matches those trials, and known safety problems. Price per day came last. We didn't test the gummies on people and took no payment from any brand; some links earn us a commission.
1. Estroven Complete Gummies: the best-studied active
Estroven's gummy uses the same rhapontic rhubarb extract, ERr 731, as its caplets, one gummy a day. A 2024 meta-analysis pooled 4 trials with 390 women and found menopause rating scale scores fell clearly more than with control. In the original 12-week trial, 109 perimenopausal women took it or placebo. A 2025 study of 5,686 women found no rise in breast cancer diagnoses.
Learn more →2. AZO Menopause Relief Daytime Gummies: genistein at the threshold
AZO's daytime gummy has one active, 30 mg of genistein, a soy isoflavone, plus 2 g of added sugar. In a 12-month Italian trial, 54 mg of genistein a day cut daily hot flashes by 22% at 3 months and 29% at 12 months more than placebo. A Cochrane review found extracts with more than 30 mg a day consistently reduced hot flashes, so AZO sits right at that line.
3. O Positiv MENO gummies: a blend built on black cohosh
Two MENO gummies give 150 mg of KSM-66 ashwagandha, 40 mg of black cohosh extract, 40 mg of chasteberry extract, vitamin D and B6, with organic cane sugar. Black cohosh is the hot flash ingredient, but a Cochrane review of 16 trials found it no better than placebo for hot flash frequency. Ashwagandha targets stress. NCCIH notes rare liver injury with both herbs.
Learn more →4. MaryRuth's Organic Menopause Gummies: tiny doses, one risky herb
MaryRuth's lists a proprietary blend of maca, kudzu, black cohosh and St. John's wort at 14.1 mg per 2 gummies, equal to 141 mg of dry herbs, plus vitamins. That is a small fraction of the doses tested in herb trials. St. John's wort can interact dangerously with many medicines, including birth control pills that many women still use in perimenopause.
Learn more →OLLY Mellow Menopause: not a gummy
OLLY is known for gummy vitamins, so many people look for OLLY menopause gummies. Its Mellow Menopause product is a capsule, $29.99 for 30, with EstroG-100 and GABA. A 5-week trial by OLLY staff found fewer hot flashes than placebo. The trial dose of EstroG-100, 514 mg, is above the 175 mg a day Europe's food safety agency judged safe.
Learn more →Menopause gummies and sugar
Gummies need sugar or syrup to hold their shape. AZO's daytime gummy has 2 g of added sugar, and O Positiv lists organic tapioca syrup and organic cane sugar as its first ingredients. A gummy or two a day is a small amount, but if you manage diabetes or count added sugar, a capsule or caplet version of the same active avoids it.
Menopause gummies by the numbers
390
30 mg
14.1 mg
$0.68
Prices are list prices on brand sites in November 2026; stores often charge less.
We may earn a commission if you buy through links on this page. It doesn't change what we recommend. How this works →
Best menopause gummies, ranked
1. Estroven Complete Menopause Relief Gummies: best evidence
Learn more →Good for
One gummy a day of ERr 731; a meta-analysis of 4 trials; $0.88 a gummy.Watch
Check price on Amazon →
Trials tied to the extract's maker. Our Amazon link is the caplet, the same extract.2. AZO Menopause Relief Daytime Gummies: cheapest
Good for
30 mg of genistein in one gummy; $20.49 for 30.Watch
Dose sits at, not above, the level where trials found benefit; a phytoestrogen.3. O Positiv MENO: for stress plus hot flashes
Good for
Ashwagandha 150 mg for stress, with black cohosh and chasteberry.Watch
$41.99 a bottle; black cohosh did no better than placebo for hot flashes.4. MaryRuth's Organic Menopause Gummies: organic, but low dose
Good for
USDA organic and vegan; adds vitamins D, B6 and B12.Watch
Only 14.1 mg of herbs; St. John's wort interacts with medicines.Not a gummy: Bonafide Relizen
Learn more →Good for
Hormone-free pollen extract; studied after breast cancer; no significant side effects.Watch
Check price on Amazon →
Two tablets a day, and up to 3 months to judge.Prescription treatment
Learn more →Good for
Hormone therapy and approved non-hormonal drugs have the strongest trials for hot flashes.Watch
Needs a prescription.
How to choose menopause gummies
- Look for the active ingredient and its dose in mg on the label, not just a list of herbs.
- Avoid St. John's wort if you take birth control pills, antidepressants or other regular medicines.
- Ask your doctor before phytoestrogen gummies such as AZO if you've had breast cancer.
- Don't stack two menopause gummies; doses of black cohosh or isoflavones add up.
- Give one product 8 to 12 weeks and track hot flashes before deciding.
When menopause gummies aren't enough
Urgent: Yellow skin, dark urine or itching on a gummy with black cohosh or ashwagandha
Stop it and get liver tests.
Urgent: Bleeding after menopause
Any bleeding a year after your last period needs a check.
More →Hot flashes that still wreck your sleep after 3 months of gummies
Ask about hormone therapy or non-hormonal prescriptions.
More →You take prescription medicines
Show the gummy label to a pharmacist before starting.
Menopause gummies: questions women ask
Do menopause gummies work?
Some ingredients do better than placebo, others don't. Estroven's rhubarb extract has the most trials, and genistein above 30 mg a day reduced hot flashes in several trials. Black cohosh, the most common gummy herb, did no better than placebo in a Cochrane review. None comes close to hormone therapy.
What are the best gummies for menopause?
On evidence, Estroven Complete Gummies come first, then AZO Menopause Relief Daytime for its genistein dose. O Positiv MENO suits you if stress is the main problem. MaryRuth's has too little of each herb and includes St. John's wort, so we rank it last.
Are menopause gummies safe?
For most healthy women, yes in the short term, but check the herbs. Black cohosh and ashwagandha have rare liver injury reports, St. John's wort interacts with many medicines, and phytoestrogens like genistein need a doctor's okay after breast cancer.
Are there perimenopause gummies?
Most menopause gummies are sold for both perimenopause and menopause. The original 12-week trial of Estroven's extract enrolled perimenopausal women. If you're still having periods and use birth control pills, avoid gummies with St. John's wort, such as MaryRuth's.
Do menopause gummies help with weight loss?
None of the four is a weight-loss product, and the trials we cite measured symptoms, not weight. A 2012 trial of EstroG-100 reported no weight gain, but that's a capsule ingredient. Strength training and protein have better evidence for midlife weight.
Related →How long do menopause gummies take to work?
Estroven says results show in as little as 28 days. The trials ran 12 weeks or more, and genistein's effect was seen at 3 months. Give one product 8 to 12 weeks before switching. Keep a simple log of hot flashes and night wakings so you can compare.
Are OLLY menopause gummies good?
OLLY's menopause product, Mellow Menopause, is a capsule, not a gummy. It costs $29.99 for 30 and has one 5-week trial run by OLLY employees, at an EstroG-100 dose above the European safety limit. On evidence, a gummy with ERr 731 is the better-supported pick.
Related →Sources
- Estroven. Complete Menopause Relief Gummies: product page, directions and price. Accessed November 12, 2026.
- Dubey VP, Sureja VP, Kheni DB. Efficacy evaluation of standardized Rheum rhaponticum root extract (ERr 731 (®)) on symptoms of menopause: A systematic review and meta-analysis study. J Biomed Res. 2024;38(3):278-286.
- AZO. Menopause Relief Daytime Gummies: product page, supplement facts and price. Accessed November 12, 2026.
- O Positiv. MENO menopause gummies and capsules: product page, supplement facts and prices. Accessed November 12, 2026.
- MaryRuth Organics. Organic Menopause Gummies: product page, blend amounts, directions and price. Accessed November 12, 2026.
- Lethaby A, Marjoribanks J, Kronenberg F, et al. Phytoestrogens for menopausal vasomotor symptoms. Cochrane Database Syst Rev. 2013;2013(12):CD001395.
- Leach MJ, Moore V. Black cohosh (Cimicifuga spp.) for menopausal symptoms. Cochrane Database Syst Rev. 2012;2012(9):CD007244.
- NCCIH. St. John’s wort: usefulness and safety.
- Heger M, Ventskovskiy BM, Borzenko I, et al. Efficacy and safety of a special extract of Rheum rhaponticum (ERr 731) in perimenopausal women with climacteric complaints: a 12-week randomized, double-blind, placebo-controlled trial. Menopause. 2006;13(5):744-59.
- Heger PW, Hotz D, Kalder M, et al. Association between Extract Rheum rhaponticum 731 (ERr 731) prescription and subsequent breast cancer. Breast Cancer Res Treat. 2025;212(1):139-148.
- Crisafulli A, Marini H, Bitto A, et al. Effects of genistein on hot flushes in early postmenopausal women: a randomized, double-blind EPT- and placebo-controlled study. Menopause. 2004;11(4):400-4.
- NCCIH. Ashwagandha: usefulness and safety.
- National Center for Complementary and Integrative Health. Black cohosh: usefulness and safety.
- OLLY. Mellow Menopause: product page, ingredients, directions, price and FAQ. Accessed November 12, 2026.
- Snigdha S, Lau E, Ademola J, et al. Effect of a novel nutraceutical combination of EstroG-100 and γ-aminobutyric acid (GABA) in attenuating symptoms of menopause in healthy adult women: a randomized double-blinded placebo-controlled study. Menopause. 2025;32(11):1036-1045.
- EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Turck D, Bresson JL, et al. Statement on the safety of EstroG-100™ as a novel food pursuant to Regulation (EC) No 258/97. EFSA J. 2017;15(5):e04778.
- NHS. Postmenopausal bleeding.
- The North American Menopause Society. The 2023 nonhormone therapy position statement of The North American Menopause Society. Menopause. 2023;30(6):573-590.
- Bonafide. Relizen product page (checked September 2026).
- Bounous VE, Cipullo I, D'Alonzo M, et al. A prospective, multicenter, randomized, double-blind placebo-controlled trial on purified and specific Cytoplasmic pollen extract for hot flashes in breast cancer survivors. Gynecol Endocrinol. 2024;40(1):2334796.
- Chang A, Kwak BY, Yi K, et al. The effect of herbal extract (EstroG-100) on pre-, peri- and post-menopausal women: a randomized double-blind, placebo-controlled study. Phytother Res. 2012;26(4):510-6.
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