Last checked September 2026 against 12 sources · Editorial policy
Estroven review
Estroven Complete contains one active ingredient, rhapontic rhubarb root extract ERr 731, taken as one caplet a day. It contains no estrogen or other hormones. In a 12-week randomized trial of 109 perimenopausal women, ERr 731 lowered menopause symptom scores and cut hot flashes from week 4 compared with placebo, with no changes in endometrial biopsies. The evidence comes mainly from one research group. It costs $19.99 for 28 caplets (checked September 2026).
Estroven Complete uses rhubarb extract ERr 731, not hormones. What its trial showed for hot flashes, safety and weight claims, and price: $19.99 for 28 caplets.
Estroven menopause relief: expectation vs reality
What people often expect
“Estroven is a hormone supplement that works like HRT”
What the evidence shows
Estroven Complete contains no synthetic, animal or human hormones; its rhubarb extract is said to act on estrogen receptor beta. Its trial results are promising but come from a few studies whose authors are linked to one company, Health Research Services. The North American Menopause Society doesn't recommend herbal supplements for hot flashes, and HRT remains the most effective treatment.
Estroven review: ingredient, studies and safety
What's in Estroven Complete
Estroven Complete Multi-Symptom Menopause Relief contains rhapontic rhubarb root extract, sold as ERr 731. The directions are one caplet a day, with or without food, at any time of day. The company says it contains no soy, caffeine or stimulants and is suitable for vegan diets. Caplets and gummies contain the same extract.
Does Estroven have estrogen in it?
No. Estroven says the product contains no synthetic, animal or human-derived hormones. According to the company, the rhubarb extract selectively stimulates estrogen receptor beta, one of two estrogen receptors in the body. In the main trial, there were no differences from placebo in endometrial biopsies, bleeding, weight or blood pressure.
Estroven for hot flashes: the trial
In a multicenter, double-blind trial, 109 perimenopausal women with menopause symptoms took ERr 731 or placebo daily for 12 weeks. By 12 weeks, total Menopause Rating Scale scores and each individual symptom fell significantly more with ERr 731. The number and severity of hot flashes were significantly lower from week 4, and menopause-specific quality of life improved.
Learn more →Estroven for perimenopause
The main ERr 731 trial was done in perimenopausal women, and the company says the product can be used for perimenopause. In a follow-up observational study lasting 96 weeks, women who continued taking ERr 731 had further small drops in symptoms, averaging less than 1.4 slight hot flashes a day by the end. Observational studies without a placebo group are weaker evidence.
Is Estroven safe?
In the trials, no adverse events were attributed to ERr 731, and there were no clinically relevant changes in safety measures over 96 weeks. A German database study of 5,686 women prescribed ERr 731 found no increase in breast cancer diagnoses compared with non-users or HRT users. Some authors of these studies work for Health Research Services.
Learn more →Estroven weight management
Estroven says Complete Menopause Relief doesn't have a demonstrated weight benefit, and trials showed no weight gain. It sells a separate Menopause Relief + Weight product. No weight-loss supplement is proven for menopause; changes in diet and activity are the evidence-based approach.
Learn more →Marketing claims vs evidence
The product page claims up to 90% fewer hot flashes and night sweats and relief of all major menopause symptoms. These are company statements. Supplements aren't FDA-approved before sale, and the company's own FAQ notes that women may get different levels of relief. The independent evidence base is small.
Estroven by the numbers
$19.99
109
4 weeks
96 weeks
The ERr 731 trials and safety studies share authors from one research company.
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Estroven vs other menopause relief options
Estroven Complete (rhubarb extract ERr 731)
Good for
Hormone-free; one randomized trial showed fewer hot flashes and lower symptom scores.Watch
Check price on Amazon →
Evidence mainly from one research group.Amberen
Learn more →Good for
Hormone-free; several company-linked trials.Watch
Check price on Amazon →
Different ingredients; mixed independent evidence.Black cohosh
Learn more →Good for
Moderate-certainty evidence in a 2026 review.Watch
Rare liver damage.Prescription non-hormonal treatment
Learn more →Good for
SSRIs, SNRIs, gabapentin and fezolinetant are recommended by NAMS.Watch
Need a prescription.
Before you buy Estroven
- Take it daily for at least 4 weeks before judging it; that's when trial results appeared.
- Don't take more than one caplet a day.
- Ask your doctor if you take other supplements or medicines.
- Compare the 28-caplet and 60-caplet packs; the larger pack costs less per caplet.
When to see a doctor instead of relying on Estroven
Estroven for menopause: questions women ask
Does Estroven work for menopause?
One 12-week randomized trial of its rhubarb extract found lower symptom scores and fewer hot flashes than placebo. The evidence is limited and mostly from one research group.
Does Estroven have estrogen in it?
No. Estroven Complete contains no synthetic, animal or human-derived hormones; its active ingredient is rhapontic rhubarb root extract.
Is Estroven good for perimenopause?
The main trial of its ingredient was in perimenopausal women and found benefit over placebo. The company says it can be used in perimenopause.
How long does Estroven take to work?
In the trial, hot flashes fell significantly from week 4. The company advises daily use for at least 28 days.
Does Estroven help with hot flashes?
In its main trial, the number and severity of hot flashes dropped significantly more than with placebo after 4 weeks. Independent confirmation is limited.
Does Estroven cause weight gain?
The company says trials of its ingredient showed no weight gain, and the main trial found no weight difference from placebo. It also says the product has no proven weight benefit.
How much does Estroven cost?
On the Estroven site, Complete Menopause Relief costs $19.99 for 28 caplets or $29.99 for 60 (checked September 2026).
Sources
- Estroven. Estroven Complete Multi-Symptom Menopause Relief product page (checked September 2026).
- Heger M, Ventskovskiy BM, Borzenko I, et al. Efficacy and safety of a special extract of Rheum rhaponticum (ERr 731) in perimenopausal women with climacteric complaints: a 12-week randomized, double-blind, placebo-controlled trial. Menopause. 2006;13(5):744-59.
- Heger PW, Hotz D, Kalder M, et al. Association between Extract Rheum rhaponticum 731 (ERr 731) prescription and subsequent breast cancer. Breast Cancer Res Treat. 2025;212(1):139-148.
- The North American Menopause Society. The 2023 nonhormone therapy position statement of The North American Menopause Society. Menopause. 2023;30(6):573-590.
- Hasper I, Ventskovskiy BM, Rettenberger R, et al. Long-term efficacy and safety of the special extract ERr 731 of Rheum rhaponticum in perimenopausal women with menopausal symptoms. Menopause. 2009;16(1):117-31.
- US Food and Drug Administration. Tainted weight loss products (weight loss product notifications).
- US Food and Drug Administration. Dietary supplements.
- NHS. Postmenopausal bleeding.
- NHS. Heavy periods.
- Radzinsky VE, Uspenskaya Y, Shulman LP, et al. Succinate-Based Dietary Supplement for Menopausal Symptoms: A Pooled Analysis of Two Identical Randomized, Double-Blind, Placebo-Controlled Clinical Trials. Obstet Gynecol Int. 2019;2019:1572196.
- Maunder A, Mardon AK, Rao V, et al. Complementary therapies for management of menopausal symptoms: a systematic review to inform the update of the International Menopause Society recommendations on women's midlife health. Climacteric. 2026;29(2):165-209.
- National Center for Complementary and Integrative Health. Black cohosh: usefulness and safety.
See our editorial policy.
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